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PNAS recent publications

1.) Scaling and self-organized criticality in proteins II.

2.) Cryo-electron tomography of mouse hepatitis virus: Insights into the structure of the coronavirion.

3.) The phage abortive infection system, ToxIN, functions as a protein-RNA toxin-antitoxin pair.

4.) Forecasting United States mortality using cohort smoking histories.

5.) Turning back from the brink: Detecting an impending regime shift in time to avert it.

6.) An overlooked pink species of land iguana in the Galapagos.

7.) O6-methylguanine-induced cell death involves exonuclease 1 as well as DNA mismatch recognition in vivo.

8.) Exploration dynamics in evolutionary games.

9.) Phytohormone-based activity mapping of insect herbivore-produced elicitors.

10.) A DNA damage response in Escherichia coli involving the alternative sigma factor, RpoS.

11.) Tyrosine phosphorylation of the BRI1 receptor kinase emerges as a component of brassinosteroid signaling in Arabidopsis.

12.) Force amplification response of actin filaments under confined compression.

13.) Gamma flicker triggers attentional selection without awareness.

14.) Structure of the Ebola VP35 interferon inhibitory domain.

15.) Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis.

16.) Stromal growth and epithelial cell proliferation in ventral prostates of liver X receptor knockout mice.

17.) Increasing Cu bioavailability inhibits A{beta} oligomers and tau phosphorylation.

18.) Crystal structure of the conserved N-terminal domain of the peroxisomal matrix protein import receptor, Pex14p.

19.) HLA class I molecules consistently present internal influenza epitopes.

20.) Inaugural Article: Direct imaging of human Rad51 nucleoprotein dynamics on individual DNA molecules.

21.) HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy.

22.) Quantifying the global cellular thiol-disulfide status.

23.) Inferring biological mechanisms from spatial analysis: Prediction of a local inhibitor in the ovary.

24.) HIV-1 Tat RNA silencing suppressor activity is conserved across kingdoms and counteracts translational repression of HIV-1.

25.) Low-barrier hydrogen bond in photoactive yellow protein.

26.) Ebf1-mediated down-regulation of Id2 and Id3 is essential for specification of the B cell lineage.

27.) Directed self-organization of single DNA molecules in a nanoslit via embedded nanopit arrays.

28.) Can neurosphere production help restore inner ear transduction?

29.) Dynamics of one-state downhill protein folding.

30.) The specificity of T cell regulation that enables self-nonself discrimination in the periphery.

31.) Transmission of allostery through the lectin domain in selectin-mediated cell adhesion.

32.) Microbe hunting in the 21st century.

33.) ChIP-on-chip significance analysis reveals large-scale binding and regulation by human transcription factor oncogenes.

34.) G protein-activated inwardly rectifying potassium channels mediate depotentiation of long-term potentiation.

35.) Neuronal activity regulates phosphorylation-dependent surface delivery of G protein-activated inwardly rectifying potassium channels.

36.) Structural basis for selectin mechanochemistry.

37.) Combined targeting of lentiviral vectors and positioning of transduced cells by magnetic nanoparticles.

38.) On the fate of anthropogenic nitrogen.

39.) Localizing interference during naming: Convergent neuroimaging and neuropsychological evidence for the function of Broca's area.

40.) Teaching Cre to follow directions.

41.) Continuous elimination of oxidized nucleotides is necessary to prevent rapid onset of cellular senescence.

42.) Constraining the loop, releasing prion infectivity.

43.) Validation of multivariate model of leaf ionome is fundamentally confounded.

44.) Acknowledgment of reviewers, 2008.

45.) A fortuitous insight into a common mode of RNA recognition by the dsRNA-specific zinc fingers.

46.) Origins of replication in Cyanothece 51142.

47.) Passive transport across bilayer lipid membranes: Overton continues to rule.

48.) Condensation of FtsZ filaments can drive bacterial cell division.

49.) Genome rhetoric and the emergence of compositional bias.

50.) Sic1-induced DNA rereplication during meiosis.

51.) The use of amphipols as universal molecular adapters to immobilize membrane proteins onto solid supports.

52.) Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent.

53.) Synaptic activity-responsive element in the Arc/Arg3.1 promoter essential for synapse-to-nucleus signaling in activated neurons.

54.) Contrasted patterns of hyperdiversification in Mediterranean hotspots.

55.) The key role of the surface membrane in why gastropod nacre grows in towers.

56.) Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells.

57.) Expression levels of a filament-specific transcriptional regulator are sufficient to determine Candida albicans morphology and virulence.

58.) Wnt signaling targets ETO coactivation domain of TAF4/TFIID in vivo.

59.) Identification of direct residue contacts in protein-protein interaction by message passing.

60.) The role of PTEN/Akt/PI3K signaling in the maintenance and viability of prostate cancer stem-like cell populations.

61.) Biallelic, ubiquitous transcription from the distal germline Ig{kappa} locus promoter during B cell development.

62.) Changes in H5N1 influenza virus hemagglutinin receptor binding domain affect systemic spread.

63.) A reappraisal of evidence for probabilistic models of allelic exclusion.

64.) Force generation by a dynamic Z-ring in Escherichia coli cell division.

65.) Viral RNA polymerase complex promotes optimal growth of 1918 virus in the lower respiratory tract of ferrets.

66.) The yeast Sup35NM domain propagates as a prion in mammalian cells.

67.) An empirical explanation of aperture effects.

68.) PKC{eta} regulates occludin phosphorylation and epithelial tight junction integrity.

69.) Simple prediction of interaction strengths in complex food webs.

70.) Resolving cadherin interactions and binding cooperativity at the single-molecule level.

71.) Whole-genome association study identifies STK39 as a hypertension susceptibility gene.

72.) A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN.

73.) DGCR8-dependent microRNA biogenesis is essential for skin development.

74.) Folding energy landscape and network dynamics of small globular proteins.

75.) A regulatory interplay between miR-27a and Runx1 during megakaryopoiesis.

76.) Structurally diverse natural products that cause potassium leakage trigger multicellularity in Bacillus subtilis.

77.) A primitive Late Pliocene cheetah, and evolution of the cheetah lineage.

78.) Unliganded gating of acetylcholine receptor channels.

79.) Evaluation of new generation Salmonella enterica serovar Typhimurium vaccines with regulated delayed attenuation to induce immune responses against PspA.

80.) Accurate SHAPE-directed RNA structure determination.

81.) Nonlinear threshold behavior during the loss of Arctic sea ice.

82.) A role for the host coatomer and KDEL receptor in early vaccinia biogenesis.

83.) Essential functions of the Williams-Beuren syndrome-associated TFII-I genes in embryonic development.

84.) A conserved protonation-dependent switch controls drug binding in the Abl kinase.

85.) Efficient colonic mucosal wound repair requires Trem2 signaling.

86.) Mapping RNA exit channel on transcribing RNA polymerase II by FRET analysis.

87.) Disruption of the SRC-1 gene in mice suppresses breast cancer metastasis without affecting primary tumor formation.

88.) Reprogramming of murine and human somatic cells using a single polycistronic vector.

89.) Great ranging associated with greater reproductive investment in mammals.

90.) Trophic cascades promote threshold-like shifts in pelagic marine ecosystems.

91.) Retraction for Prasad et al., Characterization of capsaicin synthase and identification of its gene (csy1) for pungency factor capsaicin in pepper (Capsicum sp.).

92.) Glyconanoparticles allow pre-symptomatic in vivo imaging of brain disease.

93.) Mechanism of a prototypical synthetic membrane-active antimicrobial: Efficient hole-punching via interaction with negative intrinsic curvature lipids.

94.) Distinct roles of GSK-3alpha and GSK-3beta phosphorylation in the heart under pressure overload.

95.) Replacement of normal with mutant alleles in the genome of normal human cells unveils mutation-specific drug responses.

96.) Association of the circadian rhythmic expression of GmCRY1a with a latitudinal cline in photoperiodic flowering of soybean.

97.) Incremental steps toward incompatibility revealed by Arabidopsis epistatic interactions modulating salicylic acid pathway activation.

98.) Structure of PolC reveals unique DNA binding and fidelity determinants.

99.) Population genetics of Trypanosoma brucei gambiense, the agent of sleeping sickness in Western Africa.

100.) Two-phase increase in the maximum size of life over 3.5 billion years reflects biological innovation and environmental opportunity.

101.) A robust automated system elucidates mouse home cage behavioral structure.

102.) A consensus view of DNA binding by the C family of replicative DNA polymerases.

103.) Ion-water hydrogen-bond switching observed with 2D IR vibrational echo chemical exchange spectroscopy.

104.) Use of the Rad51 promoter for targeted anti-cancer therapy.

105.) Mice lacking asparaginyl endopeptidase develop disorders resembling hemophagocytic syndrome.

106.) Simultaneous behavioral characterizations: Embracing complexity.

107.) Coastal eutrophication: Whether N and/or P should be abated depends on the dynamic mass balance.

108.) Vitamin B deficiency causes neural cell loss and cognitive impairment in the developing rat.

109.) Serum-based microRNAs: Are we blinded by potential?

110.) Molecular mechanism for the umami taste synergism.

111.) Imaging quantum confinement with optical and POWER (perturbations observed with enhanced resolution) NMR.

112.) Near-linear cost increase to reduce climate-change risk.

113.) Transformation and isolation of allelic exchange mutants of Chlamydia psittaci using recombinant DNA introduced by electroporation.

114.) Inaugural Article: Imaging the glycome.

115.) Insights into the P-to-Q conversion in the catalytic cycle of methane monooxygenase from a synthetic model system.

116.) Gene regulatory network subcircuit controlling a dynamic spatial pattern of signaling in the sea urchin embryo.

117.) Transgenic rice plants that overexpress transcription factors RF2a and RF2b are tolerant to rice tungro virus replication and disease.

118.) Topological structures in the equities market network.

119.) Slow peptide bond formation by proline and other N-alkylamino acids in translation.

120.) Redundant mechanisms mediate bristle patterning on the Drosophila thorax.

121.) Synteny and candidate gene prediction using an anchored linkage map of Astyanax mexicanus.

122.) Dissecting early regulatory relationships in the lamprey neural crest gene network.

123.) Dividing glial cells maintain differentiated properties including complex morphology and functional synapses.

124.) Targeting Nrf2 with the triterpenoid CDDO- imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice.

125.) Circuitry-based gene expression profiles in GABA cells of the trisynaptic pathway in schizophrenics versus bipolars.

126.) Regulatory logic of neuronal diversity: terminal selector genes and selector motifs.

127.) A gene regulatory network armature for T lymphocyte specification.

128.) Properties of developmental gene regulatory networks.

129.) Replication protein A and proliferating cell nuclear antigen coordinate DNA polymerase selection in 8-oxo-guanine repair.

130.) The Drosophila cell adhesion molecule Klingon is required for long-term memory formation and is regulated by Notch.

131.) Genetic analysis of interactions with eukaryotic rRNA identify the mitoribosome as target in aminoglycoside ototoxicity.

132.) Variation in dopamine genes influences responsivity of the human reward system.

133.) Structural basis for antagonism of human interleukin 18 by poxvirus interleukin 18-binding protein.

134.) The Caenorhabditis elegans vulva: a post-embryonic gene regulatory network controlling organogenesis.

135.) A regulatory module embedded in the coding region of Hoxa2 controls expression in rhombomere 2.

136.) A large-scale analysis of tissue-specific pathology and gene expression of human disease genes and complexes.

137.) Fossil evidence for the origin of spider spinnerets, and a proposed arachnid order.

138.) A chemical biology approach reveals period shortening of the mammalian circadian clock by specific inhibition of GSK-3beta.

139.) Culture, population structure, and low genetic diversity in Pleistocene hominins.

140.) Filament rigidity causes F-actin depletion from nonbinding surfaces.

141.) How the Dorsal gradient works: insights from postgenome technologies.

142.) Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen.

143.) MIG-17/ADAMTS controls cell migration by recruiting nidogen to the basement membrane in C. elegans.

144.) Prediction of incommensurate crystal structure in Ca at high pressure.

145.) Differential trafficking of AMPA and NMDA receptors by SAP102 and PSD-95 underlies synapse development.

146.) Explosively launched spores of ascomycete fungi have drag-minimizing shapes.

147.) Structural basis for cross-resistance to ribosomal PTC antibiotics.

148.) Palmitoylation gates phosphorylation-dependent regulation of BK potassium channels.

149.) Single-molecule DNA detection with an engineered MspA protein nanopore.

150.) Functional comparison of RGS9 splice isoforms in a living cell.

151.) Determination of cell fate selection during phage lambda infection.

152.) Activity-independent and subunit-specific recruitment of functional AMPA receptors at neurexin/neuroligin contacts.

153.) Origin of the sharp boundary that discriminates positive and negative selection of thymocytes.

154.) Bidirectional Ca2+-dependent control of mitochondrial dynamics by the Miro GTPase.

155.) Two-step oligoclonal development of male germ cells.

156.) Stochasticity and bistability in horizontal transfer control of a genomic island in Pseudomonas.

157.) Discovery and revision of Arabidopsis genes by proteogenomics.

158.) Adaptive protein evolution grants organismal fitness by improving catalysis and flexibility.

159.) Neurogenesis and widespread forebrain migration of distinct GABAergic neurons from the postnatal subventricular zone.

160.) Na+-mediated coupling between AMPA receptors and KNa channels shapes synaptic transmission.

161.) The crystal structure of the second Z-DNA binding domain of human DAI (ZBP1) in complex with Z-DNA reveals an unusual binding mode to Z-DNA.

162.) In vivo commitment and functional tissue regeneration using human embryonic stem cell-derived mesenchymal cells.

163.) Selectin catch-slip kinetics encode shear threshold adhesive behavior of rolling leukocytes.

164.) White spot syndrome virus protein ICP11: A histone-binding DNA mimic that disrupts nucleosome assembly.

165.) Direct role of structural dynamics in electron-lattice coupling of superconducting cuprates.

166.) Preclinical evaluation of multiple species of PEGylated recombinant phenylalanine ammonia lyase for the treatment of phenylketonuria.

167.) Identification of gene 3' ends by automated EST cluster analysis.

168.) Failure of T cell homing, reduced CD4/CD8alphaalpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice.

169.) The neuronal connexin36 interacts with and is phosphorylated by CaMKII in a way similar to CaMKII interaction with glutamate receptors.

170.) How CYCLOPS keeps an eye on plant symbiosis.

171.) A dual-signal regulatory circuit activates transcription of a set of divergent operons in Salmonella typhimurium.

172.) Essential function of Chk1 can be uncoupled from DNA damage checkpoint and replication control.

173.) Visualizing stimulus convergence in amygdala neurons during associative learning.

174.) The eocyte hypothesis and the origin of eukaryotic cells.

175.) The spt-function of Andrews.

176.) Volume-selective magnetic resonance imaging using an adjustable, single-sided, portable sensor.

177.) A proviral puzzle with a prosimian twist.

178.) Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein.

179.) Modeling the temporal evolution of the spindle assembly checkpoint and role of Aurora B kinase.

180.) Adrenal peripheral clock controls the autonomous circadian rhythm of glucocorticoid by causing rhythmic steroid production.

181.) Four-dimensional realistic modeling of pancreatic organogenesis.

182.) Analysis of nondegradative protein ubiquitylation with a monoclonal antibody specific for lysine-63-linked polyubiquitin.

183.) Highly parallel identification of essential genes in cancer cells.

184.) Trop2 identifies a subpopulation of murine and human prostate basal cells with stem cell characteristics.

185.) IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype.

186.) E3 ligase activity of BRCA1 is not essential for mammalian cell viability or homology-directed repair of double-strand DNA breaks.

187.) ATP hydrolysis is required for DEAD-box protein recycling but not for duplex unwinding.

188.) Maintenance of host variation in tolerance to pathogens and parasites.

189.) SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis.

190.) Oncogenic kinase NPM/ALK induces through STAT3 expression of immunosuppressive protein CD274 (PD-L1, B7-H1).

191.) The co-chaperone BAG3 regulates Herpes Simplex Virus replication.

192.) DEAD-box proteins can completely separate an RNA duplex using a single ATP.

193.) Antagonism of E2F-1 regulated Bnip3 transcription by NF-kappaB is essential for basal cell survival.

194.) Determination of tag density required for digital transcriptome analysis: application to an androgen-sensitive prostate cancer model.

195.) Multilayer three-dimensional super resolution imaging of thick biological samples.

196.) Growth hormone-releasing hormone as an agonist of the ghrelin receptor GHS-R1a.

197.) miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels.

198.) Visualization of IFNbeta production by plasmacytoid versus conventional dendritic cells under specific stimulation conditions in vivo.

199.) Regulation of lymphocyte progenitor survival by the proapoptotic activities of Bim and Bid.

200.) Structural origins for the product specificity of SET domain protein methyltransferases.

201.) Genome-wide analysis of cancer/testis gene expression.

202.) Unrealistic assumptions invalidate extinction estimates.

203.) Gibraltar data are too sparse to inform on Neanderthal exploitation of coastal resources.

204.) Etifoxine improves peripheral nerve regeneration and functional recovery.

205.) Small-interfering RNAs from natural antisense transcripts derived from a cellulose synthase gene modulate cell wall biosynthesis in barley.

206.) Protective T cell immunity against respiratory syncytial virus is efficiently induced by recombinant BCG.

207.) Cross-modal individual recognition in domestic horses (Equus caballus).

208.) Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface.

209.) IL-10 and PD-L1 operate through distinct pathways to suppress T-cell activity during persistent viral infection.

210.) An essential role for the antiviral endoribonuclease, RNase-L, in antibacterial immunity.

211.) Random walk in orthogonal space to achieve efficient free-energy simulation of complex systems.

212.) Reduction of CCR5 with low-dose rapamycin enhances the antiviral activity of vicriviroc against both sensitive and drug-resistant HIV-1.

213.) The nuclear membrane organization of leukotriene synthesis.

214.) The Candida albicans pescadillo homolog is required for normal hypha-to-yeast morphogenesis and yeast proliferation.

215.) Rationalizing translation attenuation in the network architecture of the unfolded protein response.

216.) Integrated microfluidic bioprocessor for single-cell gene expression analysis.

217.) Quantitative criteria for native energetic heterogeneity influences in the prediction of protein folding kinetics.

218.) Correlation between the conformational states of F1-ATPase as determined from its crystal structure and single-molecule rotation.

219.) Increasing corn for biofuel production reduces biocontrol services in agricultural landscapes.

220.) Antioxidant activity of growth hormone-releasing hormone antagonists in LNCaP human prostate cancer line.

221.) Synergistic effects of climate-related variables suggest future physiological impairment in a top oceanic predator.

222.) Small G proteins exhibit pattern sensitivity in MAPK activation during the induction of memory and synaptic facilitation in Aplysia.

223.) Akt2 overexpression plays a critical role in the establishment of colorectal cancer metastasis.

224.) Role of root UV-B sensing in Arabidopsis early seedling development.

225.) A postnatal switch of CELF and MBNL proteins reprograms alternative splicing in the developing heart.

226.) Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli.

227.) Protein kinase A inhibits a consolidated form of memory in Drosophila.

228.) Single virus detection from the reactive shift of a whispering-gallery mode.

229.) Climate regulation of fire emissions and deforestation in equatorial Asia.

230.) Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate.

231.) The role of nutricline depth in regulating the ocean carbon cycle.

232.) A transitional endogenous lentivirus from the genome of a basal primate and implications for lentivirus evolution.

233.) Alkaline polymer electrolyte fuel cells completely free from noble metal catalysts.

234.) NPY genes and AGC kinases define two key steps in auxin-mediated organogenesis in Arabidopsis.

235.) Human Rad52-mediated homology search and annealing occurs by continuous interactions between overlapping nucleoprotein complexes.

236.) Drosophila D1 dopamine receptor mediates caffeine-induced arousal.

237.) Cytokinins are central regulators of cambial activity.

238.) Transcription factor neuromancer/TBX20 is required for cardiac function in Drosophila with implications for human heart disease.

239.) Long-chain carboxychromanols, metabolites of vitamin E, are potent inhibitors of cyclooxygenases.

240.) Development of tough, low-density titanium-based bulk metallic glass matrix composites with tensile ductility.

241.) Fluorescence detection of the movement of single KcsA subunits reveals cooperativity.

242.) GRIP1-associated SET-domain methyltransferase in glucocorticoid receptor target gene expression.

243.) Vectorial proton transfer coupled to reduction of O2 and NO by a heme-copper oxidase.

244.) A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity.

245.) Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo.

246.) Fractalization drives crystalline states in a frustrated spin system.

247.) Computation of mutual fitness by competing bacteria.

248.) Static and dynamic correlations in water at hydrophobic interfaces.

249.) CYCLOPS, a mediator of symbiotic intracellular accommodation.

250.) Tissue-specific PKA inhibition using a chemical genetic approach and its application to studies on sperm capacitation.

251.) Genetic analysis of crawling and swimming locomotory patterns in C. elegans.

252.) Late neandertals in southeastern Iberia: Sima de las Palomas del Cabezo Gordo, Murcia, Spain.

253.) Aglycosylated immunoglobulin G1 variants productively engage activating Fc receptors.

254.) Multiplex protein assays based on real-time magnetic nanotag sensing.

255.) Memory T-lymphocyte survival does not require T-cell receptor expression.

256.) A type II NAD(P)H dehydrogenase mediates light-independent plastoquinone reduction in the chloroplast of Chlamydomonas.

257.) The structural basis of integrin-linked kinase-PINCH interactions.

258.) Cloning and characterization of SARI (suppressor of AP-1, regulated by IFN).

259.) Dynamic cross-frequency couplings of local field potential oscillations in rat striatum and hippocampus during performance of a T-maze task.

260.) Early visual brain areas reflect the percept of an ambiguous scene.

261.) Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins.

262.) A selective G betagamma-linked intracellular mechanism for modulation of a ligand-gated ion channel by ethanol.

263.) The RNA binding protein CPEB regulates dendrite morphogenesis and neuronal circuit assembly in vivo.

264.) CTCF-dependent enhancer-blocking by alternative chromatin loop formation.

265.) In situ assembly of linked geometrically coupled microdevices.

266.) Discontinuous movement of mRNP particles in nucleoplasmic regions devoid of chromatin.

267.) Ubiquitin signals autophagic degradation of cytosolic proteins and peroxisomes.

268.) Screening plasmonic materials using pyramidal gratings.

269.) Recognition and repair of UV lesions in loop structures of duplex DNA by DASH-type cryptochrome.

270.) CTLA-4 blockade enhances polyfunctional NY-ESO-1 specific T cell responses in metastatic melanoma patients with clinical benefit.

271.) One-step assembly in yeast of 25 overlapping DNA fragments to form a complete synthetic Mycoplasma genitalium genome.

272.) The defect in T-cell regulation in NOD mice is an effect on the T-cell effectors.

273.) Growth-rate-dependent partitioning of RNA polymerases in bacteria.

274.) The Nore1B/Mst1 complex restrains antigen receptor-induced proliferation of naive T cells.

275.) Optical methodology for detecting histologically unapparent nanoscale consequences of genetic alterations in biological cells.

276.) RNA interference and retinoblastoma-related genes are required for repression of endogenous siRNA targets in Caenorhabditis elegans.

277.) Beta-Catenin downregulation attenuates ischemic cardiac remodeling through enhanced resident precursor cell differentiation.

278.) How main-chains of proteins explore the free-energy landscape in native states.

279.) Effect of habitat area and isolation on fragmented animal populations.

280.) Finding the corridor more traveled.

281.) Crude demographic proxy reveals nothing about Paleoindian population.

282.) California archaeological record consistent with Younger Dryas disruptive event.

283.) Standards of evidence and Paleoindian demographics.

284.) Southeastern data inconsistent with Paleoindian demographic reconstruction.

285.) Biostratigraphic evidence supports Paleoindian population disruption at approximately 12.9 ka.

286.) Sleep, arousal, and rhythms in flies.

287.) Crystal structure of a near-full-length archaeal MCM: functional insights for an AAA+ hexameric helicase.

288.) Opening and closing the metabolite gate.

289.) Solvent dramatically affects protein structure refinement.

290.) De novo generation of a transmissible spongiform encephalopathy by mouse transgenesis.

291.) The archaebacterial origin of eukaryotes.

292.) Nuclear retention of ICP0 in cells exposed to HDAC inhibitor or transfected with DNA before infection with herpes simplex virus 1.

293.) Noninvasive prenatal diagnosis of fetal chromosomal aneuploidy by massively parallel genomic sequencing of DNA in maternal plasma.

294.) Dendritic cells in the thymus contribute to T-regulatory cell induction.

295.) Retinoic acid-gated sequence-specific translational control by RARalpha.

296.) A cytokine-neutralizing antibody as a structural mimetic of 2 receptor interactions.

297.) TRPV6 is not required for 1alpha,25-dihydroxyvitamin D3-induced intestinal calcium absorption in vivo.

298.) A mixability theory for the role of sex in evolution.

299.) Thermodynamics and kinetics of protein folding under confinement.

300.) Retraction for Prasad et al., Characterization of capsaicin synthase and identification of its gene (csy1) for pungency factor capsaicin in pepper (Capsicum sp.).

301.) The size variance relationship of business firm growth rates.

302.) AGO1-miR173 complex initiates phased siRNA formation in plants.

303.) Adenosine in the tuberomammillary nucleus inhibits the histaminergic system via A1 receptors and promotes non-rapid eye movement sleep.

304.) Quantifying errors in trace species transport modeling.

305.) A dynamic zone defines interneuron remodeling in the adult neocortex.

306.) Starch grains on human teeth reveal early broad crop diet in northern Peru.

307.) Conformal geometry of the retinal nerve fiber layer.

308.) SMRT repression of nuclear receptors controls the adipogenic set point and metabolic homeostasis.

309.) Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement.

310.) Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism.

311.) MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and Myc.

312.) Genetic architecture of complex traits: large phenotypic effects and pervasive epistasis.

313.) Transduction of the cytoplasmic domain of CTLA-4 inhibits TcR-specific activation signals and prevents collagen-induced arthritis.

314.) Phospholipase C{beta}3 in mouse and human dorsal root ganglia and spinal cord is a possible target for treatment of neuropathic pain.

315.) Aneuploid sperm formation in rainbow trout exposed to the environmental estrogen 17{alpha}-ethynylestradiol.

316.) How social status shapes race.

317.) nemy encodes a cytochrome b561 that is required for Drosophila learning and memory.

318.) Receptor noise limitations on chemotactic sensing.

319.) Chromosome 15q25.1 genetic markers associated with level of response to alcohol in humans.

320.) STN1 protects chromosome ends in Arabidopsis thaliana.

321.) Interplay of local hydrogen-bonding and long-ranged dipolar forces in simulations of confined water.

322.) Crystal structure of a translation termination complex formed with release factor RF2.

323.) Three-dimensional microfluidic devices fabricated in layered paper and tape.

324.) Cytokinin signaling regulates cambial development in poplar.

325.) Antagonistic selection from predators and pathogens alters food-web structure.

326.) Modulation of RNA polymerase II subunit composition by ubiquitylation.

327.) Efficient replication of rhesus cytomegalovirus variants in multiple rhesus and human cell types.

328.) ERK-mediated regulation of leukotriene biosynthesis by androgens: a molecular basis for gender differences in inflammation and asthma.

329.) The absence of reward induces inequity aversion in dogs.

330.) A DNA transposon-based approach to validate oncogenic mutations in the mouse.

331.) Tcl1 functions as a transcriptional regulator and is directly involved in the pathogenesis of CLL.

332.) Dynein pulls microtubules without rotating its stalk.

333.) Cells of adult brain germinal zone have properties akin to hair cells and can be used to replace inner ear sensory cells after damage.

334.) Stabilizing effect of knots on proteins.

335.) The dietary phytochemical indole-3-carbinol is a natural elastase enzymatic inhibitor that disrupts cyclin E protein processing.

336.) Superfamily phenomena and motifs of networks induced from time series.

337.) A mouse model for EML4-ALK-positive lung cancer.

338.) A redox-sensitive peroxiredoxin that is important for longevity has tissue- and stress-specific roles in stress resistance.

339.) Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases.

340.) Analysis of cryo-electron microscopy images does not support the existence of 30-nm chromatin fibers in mitotic chromosomes in situ.

341.) Expanding metabolism for biosynthesis of nonnatural alcohols.

342.) Links between plant litter chemistry, species diversity, and below-ground ecosystem function.

343.) Experimental evidence that human impacts drive fire ant invasions and ecological change.

344.) Genome-wide expression profiling reveals distinct clusters of transcriptional regulation during bovine preimplantation development in vivo.

345.) Amino acids with an intermolecular proton bond as proton storage site in bacteriorhodopsin.

346.) In vitro assembly of the Tomato bushy stunt virus replicase requires the host Heat shock protein 70.

347.) Overlapping functions of the four class XI myosins in Arabidopsis growth, root hair elongation, and organelle motility.

348.) Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells.

349.) Anopheles gambiae males produce and transfer the vitellogenic steroid hormone 20-hydroxyecdysone to females during mating.

350.) Contribution of KCNQ2 and KCNQ3 to the medium and slow afterhyperpolarization currents.

351.) Role of prostaglandin D2 receptor DP as a suppressor of tumor hyperpermeability and angiogenesis in vivo.

352.) Enhanced translocation of single DNA molecules through alpha-hemolysin nanopores by manipulation of internal charge.

353.) Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons.

354.) Noninvasive prenatal diagnosis of monogenic diseases by digital size selection and relative mutation dosage on DNA in maternal plasma.

355.) HIV infection-associated immune activation occurs by two distinct pathways that differentially affect CD4 and CD8 T cells.

356.) A crystallographic snapshot of tyrosine trans-phosphorylation in action.

357.) Disentangling the effects of forage, social rank, and risk on movement autocorrelation of elephants using Fourier and wavelet analyses.

358.) Rapid evolution of Cse4p-rich centromeric DNA sequences in closely related pathogenic yeasts, Candida albicans and Candida dubliniensis.

359.) The chromosome 3p21.3-encoded gene, LIMD1, is a critical tumor suppressor involved in human lung cancer development.

360.) Efficient transposition of the Tol2 transposable element from a single-copy donor in zebrafish.

361.) Rods-cones and melanopsin detect light and dark to modulate sleep independent of image formation.

362.) A dimer-specific function of the transcription factor NFATp.

363.) NKT cells prevent chronic joint inflammation after infection with Borrelia burgdorferi.

364.) Bivalent domains enforce transcriptional memory of DNA methylated genes in cancer cells.

365.) The photoreversible fluorescent protein iLOV outperforms GFP as a reporter of plant virus infection.

366.) Fractal reorientation clocks: Linking animal behavior to statistical patterns of search.

367.) An emerging movement ecology paradigm.

368.) A movement ecology paradigm for unifying organismal movement research.

369.) Movement ecology of migration in turkey vultures.

370.) Trends and missing parts in the study of movement ecology.

371.) Individual movement behavior, matrix heterogeneity, and the dynamics of spatially structured populations.

372.) A framework for generating and analyzing movement paths on ecological landscapes.

373.) Tracking butterfly movements with harmonic radar reveals an effect of population age on movement distance.

374.) Multiple movement modes by large herbivores at multiple spatiotemporal scales.

375.) Understanding strategies for seed dispersal by wind under contrasting atmospheric conditions.

376.) Geomagnetic imprinting: A unifying hypothesis of long-distance natal homing in salmon and sea turtles.

377.) The movement ecology and dynamics of plant communities in fragmented landscapes.

378.) Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain.

379.) Response to Harve et al: Effects on protein folding speed and shape despite possible size changes in Ficoll 70.

380.) Macromolecular crowding in vitro as means of emulating cellular interiors: when less might be more.

381.) Coastal marine eutrophication: Control of both nitrogen and phosphorus is necessary.

382.) Delaying insect resistance to transgenic crops.

383.) Multiple domestications do not appear monophyletic.

384.) Stabilization of HIF-1alpha is critical to improve wound healing in diabetic mice.

385.) Endogenous methyl palmitate modulates nicotinic receptor-mediated transmission in the superior cervical ganglion.

386.) Sulfiredoxin is an AP-1 target gene that is required for transformation and shows elevated expression in human skin malignancies.

387.) Profile of Sergio Ferreira.

388.) Critical role of ROR-gammat in a new thymic pathway leading to IL-17-producing invariant NKT cell differentiation.

389.) The return of pretransfer editing in protein synthesis.

390.) Evolutionary ecology, antibiosis, and all that rot.

391.) Prolyl hydroxylase inhibition during hyperoxia prevents oxygen-induced retinopathy.

392.) The human genome in the LINE of fire.

393.) Enhancing nuclear receptor-induced transcription requires nuclear motor and LSD1-dependent gene networking in interchromatin granules.

394.) In vitro selection of a neutralization-resistant hepatitis C virus escape mutant.

395.) Depolarization-activated gating pore current conducted by mutant sodium channels in potassium-sensitive normokalemic periodic paralysis.

396.) Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth.

397.) Left-right asymmetry of the hippocampal synapses with differential subunit allocation of glutamate receptors.

398.) Genome-scale reconstruction of the Lrp regulatory network in Escherichia coli.

399.) Ultrathin self-assembled fibrin sheets.

400.) Canopy nitrogen, carbon assimilation, and albedo in temperate and boreal forests: Functional relations and potential climate feedbacks.

401.) mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.

402.) Characterizing heterogeneous cellular responses to perturbations.

403.) Dynamical roles of metal ions and the disulfide bond in Cu, Zn superoxide dismutase folding and aggregation.

404.) Nanodomain fragmentation and local rearrangements in CdSe under pressure.

405.) The nuclear corepressor, NCoR, regulates thyroid hormone action in vivo.

406.) A PIIB-type Ca2+-ATPase is essential for stress adaptation in Physcomitrella patens.

407.) A genomic approach to colon cancer risk stratification yields biologic insights into therapeutic opportunities.

408.) Amyloid-beta overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins.

409.) Requirement for binding multiple ATPs to convert a GroEL ring to the folding-active state.

410.) Age-dependent and age-independent human memory persistence is enhanced by delayed posttraining methylphenidate administration.

411.) A geometric constraint, the head-to-tail exclusion rule, may be the basis for the isolated-pentagon rule in fullerenes with more than 60 vertices.

412.) Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.

413.) Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane.

414.) Cell shape and cell-wall organization in Gram-negative bacteria.

415.) Identification of Barkor as a mammalian autophagy-specific factor for Beclin 1 and class III phosphatidylinositol 3-kinase.

416.) Extracellular proteolysis by matrix metalloproteinase-9 drives dendritic spine enlargement and long-term potentiation coordinately.

417.) Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling.

418.) S layer protein A of Lactobacillus acidophilus NCFM regulates immature dendritic cell and T cell functions.

419.) Growth of uterine leiomyomata among premenopausal black and white women.

420.) Alphavirus-derived small RNAs modulate pathogenesis in disease vector mosquitoes.

421.) Economics, cultural transmission, and the dynamics of the sex ratio at birth in China.

422.) Global temperature responses to current emissions from the transport sectors.

423.) Kinesin's cover-neck bundle folds forward to generate force.

424.) Membrane shape as a reporter for applied forces.

425.) Complete modification of TCR specificity and repertoire selection does not perturb a CD8+ T cell immunodominance hierarchy.

426.) A zinc-dependent adhesion module is responsible for intercellular adhesion in staphylococcal biofilms.

427.) Storage of cellular 5' mRNA caps in P bodies for viral cap-snatching.

428.) Functional network reorganization during learning in a brain-computer interface paradigm.

429.) Temperature regulates limb length in homeotherms by directly modulating cartilage growth.

430.) HDAC2 blockade by nitric oxide and histone deacetylase inhibitors reveals a common target in Duchenne muscular dystrophy treatment.

431.) Ca2+ bursts occur around a local minimal concentration of attractant and trigger sperm chemotactic response.

432.) Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis.

433.) Nonadiabatic dissociation dynamics in H2O: Competition between rotationally and nonrotationally mediated pathways.

434.) Regulation of CD8+ regulatory T cells: Interruption of the NKG2A-Qa-1 interaction allows robust suppressive activity and resolution of autoimmune disease.

435.) Increased survival of western corn rootworm on transgenic corn within three generations of on-plant greenhouse selection.

436.) Embryo fossilization is a biological process mediated by microbial biofilms.

437.) Motion and disparity processing informs Bayesian 3D motion estimation.

438.) The payoff of conservation investments in tropical countryside.

439.) Synthetic recombinant bat SARS-like coronavirus is infectious in cultured cells and in mice.

440.) A role of Pygopus as an anti-repressor in facilitating Wnt-dependent transcription.

441.) Postperovskite phase equilibria in the MgSiO3-Al2O3 system.

442.) Generation of a functional and durable vascular niche by the adenoviral E4ORF1 gene.

443.) L1 recombination-associated deletions generate human genomic variation.

444.) CD4 cell-secreted, posttranslationally modified cytokine GIF suppresses Th2 responses by inhibiting the initiation of IL-4 production.

445.) Stress-driven buckling patterns in spheroidal core/shell structures.

446.) Defects in CTLA-4 are associated with abnormal regulatory T cell function in rheumatoid arthritis.

447.) A structural and biochemical basis for PAPS-independent sulfuryl transfer by aryl sulfotransferase from uropathogenic Escherichia coli.

448.) Molecular and cellular components of the mating machinery in Anopheles gambiae females.

449.) Identification of a receptor required for the anti-inflammatory activity of IVIG.

450.) Inhibition of cyclooxygenase activity blocks cell-to-cell spread of human cytomegalovirus.

451.) Stimulation of neural regeneration in the mouse retina.

452.) Comparison of successive transition states for folding reveals alternative early folding pathways of two homologous proteins.

453.) A highly prevalent and genetically diversified Picornaviridae genus in South Asian children.

454.) Regulation of peptide import through phosphorylation of Ubr1, the ubiquitin ligase of the N-end rule pathway.

455.) Structural consequences of effector protein complex formation in a diiron hydroxylase.

456.) Comparing face patch systems in macaques and humans.

457.) In vitro unfolding of yeast multicopper oxidase Fet3p variants reveals unique role of each metal site.

458.) Complexin II plays a positive role in Ca2+-triggered exocytosis by facilitating vesicle priming.

459.) Extinction and resurrection in gene networks.

460.) Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium.

461.) Electron tomography of early melanosomes: implications for melanogenesis and the generation of fibrillar amyloid sheets.

462.) Memory-like CD8+ and CD4+ T cells cooperate to break peripheral tolerance under lymphopenic conditions.

463.) Pruning and loss of excitatory synapses by the parkin ubiquitin ligase.

464.) MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia.

465.) Forkhead Box m1 transcription factor is required for perinatal lung function.

466.) A genetically encoded fluorescent sensor of ERK activity.

467.) Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia.

468.) The hormonal action of IGF1 in postnatal mouse growth.

469.) Ordered cyclic motifs contribute to dynamic stability in biological and engineered networks.

470.) Termination codon-dependent translation of partially overlapping ndhC-ndhK transcripts in chloroplasts.

471.) Maternal transfer of xenobiotics and effects on larval striped bass in the San Francisco Estuary.

472.) Insular hypocretin transmission regulates nicotine reward.

473.) Role of the hsp70 cochaperone BAG1 in glucocorticoid receptor function and stress-related diseases.

474.) CP1-dependent partitioning of pretransfer and posttransfer editing in leucyl-tRNA synthetase.

475.) Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth.

476.) Riparian corridors enhance movement of a forest specialist bird in fragmented tropical forest.

477.) Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo.

478.) Phage phi29 protein p56 prevents viral DNA replication impairment caused by uracil excision activity of uracil-DNA glycosylase.

479.) Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron.

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